H-NOX Properties
H-NOX is a unique, stable and non-reactive heme-binding protein family with tunable affinity for oxygen
Individual products can be designed for different levels of physiologic oxygen need
Reduced reactivity of oxygen-bound H-NOX with nitric oxide (NO), the body’s natural vasoregulator, results in a negligible risk of hypertension
OMX Products
H-NOX-based OMX products are sized for optimal efficacy
Individual products are engineered with desired circulation half-lives and tissue penetration profiles
Mechanism of Action
OMX lead candidates deliver oxygen deep into hypoxic tissues
OMX products retain oxygen until reaching hypoxic microenvironments, whereas red blood cells, which release oxygen at physiologic (venous) oxygen levels, are depleted before reaching hypoxic microenvironments
