H-NOX Properties

H-NOX is a unique, stable and non-reactive heme-binding protein family with tunable affinity for oxygen


Individual products can be designed for different levels of physiologic oxygen need

Reduced reactivity of oxygen-bound H-NOX with nitric oxide (NO), the body’s natural vasoregulator, results in a negligible risk of hypertension

OMX Products

H-NOX-based OMX products are sized for optimal efficacy


Individual products are engineered with desired circulation half-lives and tissue penetration profiles

Mechanism of Action

OMX lead candidates deliver oxygen deep into hypoxic tissues


OMX products retain oxygen until reaching hypoxic microenvironments, whereas red blood cells, which release oxygen at physiologic (venous) oxygen levels, are depleted before reaching hypoxic microenvironments